Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10426 | AZ12601011 | ALK | Angiogenesis; Tyrosine Kinase/Adaptors |
AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively targeting ALK4, TGFBR1, and ALK7, AZ12601011 effectively inhibits the phosphorylation of SMAD2. Additionally, it has been shown to hinder the growth and metastasis of mammary tumors [1]. |